1305: Evaluation of Levetiracetam Dosing Strategies for Seizure Prophylaxis in Traumatic Brain Injury
نویسندگان
چکیده
منابع مشابه
Retrospective analysis of levetiracetam compared to phenytoin for seizure prophylaxis in adults with traumatic brain injury.
BACKGROUND Phenytoin is standard of care for seizure prophylaxis following traumatic brain injury (TBI). Levetiracetam, an alternative antiepileptic drug, is utilized for seizure prophylaxis despite limited data supporting its use. OBJECTIVE Our primary outcome was post-TBI seizure activity measured by electroencephalogram (EEG) for levetiracetam versus phenytoin. Secondary outcomes were leng...
متن کاملRole of Intravenous Levetiracetam in Seizure Prophylaxis of Severe Traumatic Brain Injury Patients
Traumatic brain injury (TBI) can cause seizures and the development of epilepsy. The incidence of seizures varies from 21% in patients with severe brain injuries to 50% in patients with war-related penetrating TBI. In the acute and sub-acute periods following injury, seizures can lead to increased intracranial pressure and cerebral edema, further complicating TBI management. Anticonvulsants can...
متن کاملSeizure Prophylaxis in Patients with Traumatic Brain Injury (tbi)
EVIDENCE DEFINITIONS Class I: Prospective randomized controlled trial. Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies. Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion. Technology assessment: A technology study which doe...
متن کاملSeizure Prophylaxis in Patients with Traumatic Brain Injury (tbi)
EVIDENCE DEFINITIONS Class I: Prospective randomized controlled trial. Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies. Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion. Technology assessment: A technology study which doe...
متن کاملComparison of levetiracetam versus phenytoin for seizure prophylaxis in patients with traumatic brain injury: A meta-analysis
ion sheets. Extracted data included patient’s demographics, study type, intervention, and outcome. We defined seizures as primary outcome. 1184 unduplicated papers identified by our search of which 1106 were excluded by reading the abstract and titles. 72 papers were removed by reading the full text. Finally 6 studies (Cohort studies) were selected for analysis. There is no superiority of eithe...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2020
ISSN: 0090-3493
DOI: 10.1097/01.ccm.0000731108.11792.13